Fluconazole is a member of a new class of triazole antifungal agents which inhibits Cytochrome P-450 dependent enzymes resulting in blocked ergosterole synthesis.

1. Mucosal candidiasis: These include oropharyngeal, esophageal, non-invasive Broncho-pulmonary infections, candiduria, mucocutaneous & chronic oral atrophic candidiasis (denture sore mouth). Normal hosts & patients with compromised immune function may be treated.
2. Systemic candidiasis: Include candidemia, disseminated candidiasis & other form of invasive candidial infections.
3. Genital candidiasis: Vaginal candidiasis, acute or recurrent, candidal balanitis.

4. Prevention of fungal infections: Prevention of fungal infections in patients with malignancy who are predisposed to such infections as a result of cytotoxic chemotherapy or radiotherapy.

5. Cryptococcosis:
   Including cyptococcal meningitis & infections of other sites (e.g. pulmonary, cutaneous). Normal hosts and patients with AIDS, Organ transplants or other causes of Immunosuppression may be treated. Fluconazole can be used as maintenance therapy to prevent relapse of cryptococcal disease in patient with AIDS.

Funzil Capsules are contraindicated in patients with known hypersensitivity to the drug or to related azole compounds & in advanced liver disease.

Cautions should be exercised in renal impairment, pregnancy, breast feeding & in raised liver enzymes. The use of Funzil in nursing mothers is not recommended. The use of Funzil in children below 1 year is also not recommended.

Funzil is generally well tolerated. The commonest side effects associated with Funzil are nausea, headache, skin rash, abdominal pain, vomiting, diarrhoea, flatulence & elevated liver function values.

In Adults:

1. Oropharyngeal Candidiasis: 50-100 mg once daily for 7-14 days.
2. Oesophageal Candidiasis: 50-100 mg once daily for 14-30 days.
3. Vaginal Candidiasis: 150 mg by month as a single oral dose.
4. Systemic Candidiasis: 400 mg as initial dose followed by 200 mg daily for 28 days or longer based on clinical response.
5.  Acute cryptococcal meningitis & other cryptococcal infections: 400 mg as initial dose followed by 200 to 400 mg daily, duration of treatment depending on clinical & mycological response.
6. Funzil may also be used in daily doses of 100-200 mg to prevent relapse following a primary course of antifungal treatment for acute cryptococcal meningitis.
7. In immunocompromised patients at risk of fungal infections Funzil may be given prophylactically in a dose of 50-100 mg daily.
8. For dermal infections including tinea pedis, corporis, cruris and candida infections, the recommended dosage is 150 mg once weekly or 50mg once daily. Duration of treatment is 2-4 weeks, but tinea pedis may require treatment up to 6 weeks. 
9. In Tinea Versicolor, the recommended dose is 300 mg once weekly for 2-3weeks.
10. For deep endemic mycosis, doses of 200-400mg daily for up to 2 years may be required. The duration therapy should be individualized but range from 11-24 months with Coccidiomycosis, 2-17 months with Paracoccidioidomycosis. 1-16 months with Sporotrichosis and 3-17 months for Histoplasmosis.

Protect from sunlight and moisture. Keep out of the reach of children. Store below 30°C.

What is the active ingredient in Funzil capsules?
Funzil capsules contain Fluconazole 150mg, a triazole antifungal agent.

1. What is the mechanism of action of Fluconazole?
   Fluconazole inhibits fungal cytochrome P-450 dependent enzymes, leading to blocked ergosterol synthesis, a crucial component of the fungal cell wall.
2. For which fungal infections is Funzil indicated? 
   Funzil is indicated for a broad spectrum of fungal infections, including:
   Mucosal candidiasis (oropharyngeal, esophageal, non-invasive bronchopulmonary) 

   Systemic candidiasis (candidemia, disseminated candidiasis)
   Genital candidiasis (vaginal, balanitis)
   Cryptococcosis (meningitis, infections of other sites)
   Prophylaxis of fungal infections in immunocompromised patients
   Dermatophytic infections (tinea pedis, corporis, cruris)
   Tinea versicolor
   Deep endemic mycoses (coccidioidomycosis, paracoccidioidomycosis, sporotrichosis, histoplasmosis)

3. Who should not take Funzil?
   Funzil is contraindicated in patients with known hypersensitivity to Fluconazole or related azoles and advanced liver disease. Also, Funzil is not recommended for use in nursing mothers or children below 1 year of age.

4. What are the precautions for using Funzil?
   Caution is advised in patients with: Renal impairment, Pregnancy, Breastfeeding, Raised liver enzymes.

5. What are the common side effects of Funzil? 
   Funzil is generally well-tolerated, but common side effects include: Nausea, Headache, Skin rash, Abdominal pain, Vomiting, Diarrhea, Flatulence, Elevated liver function values.

6. What is the recommended dosage of Funzil for oropharyngeal candidiasis?
   The recommended dosage is 50-100mg once daily for 7-14 days. (for further information please see patient leaflet)

7. How long should Funzil be taken for esophageal candidiasis?
   The recommended dosage is 50-100mg once daily for 14-30 days. (for further information please see patient leaflet)

8. What is the single-dose treatment for vaginal candidiasis?
   The recommended dosage is a single 150mg oral dose. (for further information please see patient leaflet)

9. What is the dosage regimen for systemic candidiasis?
   The initial dose is 400mg, followed by 200mg daily for 28 days or longer depending on clinical response. (for further information please see patient leaflet)

10. How should Funzil be stored? 
    Protect Funzil capsules from sunlight and moisture. Store below 30°C and keep out of reach of children.

11. What is the pack size of Funzil Capsule?
    Funzil is available as 150mg 1’s capsule.